Reduced cleanroom ventilation rates
F. Hoffmann-La Roche Inc. (Roche; www.roche.com) recognizes that the ventilation rates needed to ensure cleanroom manufacturing environmental standards can result in high energy intensity, and are thus a focus of optimization across the enterprise. To improve the energy efficiency of its cleanrooms, the manufacturing site in Oceanside, California USA operated by Roche's Genentech subsidiary collaborated with the Roche Global Engineering team to implement a risk-based approach to achieve lower air changes during operation without adversely impacting the facility, equipment, or reliability, while meeting environmental requirements. The implemented changes reduced air flow volume by 165,000 cfm (cubic feet per minute), resulting in a 14% decrease in energy consumption and GHG emissions for the site, and over $678,000 cost savings per year.
Name of Organization
USA Genentech / F. Hoffmann-La Roche Inc., global project
July / August 2023 | ISPE | International Society for Pharmaceutical Engineering